The simple analogy to computer hardware and software illustrates the difficulty in psychiatry. One can understand all of the hardware of a computer system, but this will not explain if or how the computer can run word processing software, video games, instant message or be susceptible to a virus, or make any predictions about the behavior of this software in the real world (for example, no computer technician could predict the writing of this paper, nor, by changing the hardware, alter the content of this paper.) Hardware is finite, but software is infinite, or as infinite as is thought. Without understanding the mechanism of thought, or at least how thoughts or states can affect mood, then a pharmacology of the brain will simply tread water with no progress towards either treatment or diagnosis. One cannot permanently alter mood without at least simultaneously altering thought. In a sense, there is more logic to the psychological approach, or at least in conjunction with medications, because if software (thought) is the problem, more software is the cure. While the applicability of “therapy” in schizophrenia may be debatable, there is no reason as yet to decide that any other approach is applicable to mood disorders such as depression or anxiety, and absolutely no evidentiary reason to assume that pharmacology is the superior approach. It is not necessarily faster nor more consistently reliable.